Novel Brønsted Acid Catalyzed C-C Bond Activation and α-Alkylation of Ketones

A novel approach for the α-alkylation of ketones was developed using Brønsted acid-catalyzed C-C bond cleavage. Both aromatic and aliphatic ketones reacted smoothly with 2-substituted 1,3-diphenylpropane-1,3-diones to afford α-alkylation products with high yields and with excellent regioselectivity, in which the 1,3-dicarbonyl group acted as a leaving group in the presence of the catalyst TfOH. Mechanism experiments showed that the β-C-C bond cleavage of diketone and the shift of the equilibrium towards the enol formation from ketone are driving forces that induce the desired products.


Introduction
Selective carbon-carbon bond (C-C bond) activation is a significant strategy in synthetic organic chemistry.It attracts a lot of attention because of its scientific interest and potential utility in organic synthesis [1,2].C-C bond activation is a new concept that differs from conventional organic synthesis, which involves obtaining the desired molecules by cracking easily obtainable organic materials.It is also a challenge in organic chemistry because C-C bond activation is thermo-dynamically much less favored than C-C bond formation [3,4].Therefore, many processes have been developed to activate the relatively inert C sp3 -C sp3 bonds.In general, the reported methods are mainly based on using late transition metals, such as rhodium [5,6], ruthenium [7], palladium [8,9], nickel [10], and other metals [11][12][13].To improve economic performance, some inexpensive and readily abundant metals, such as iron, have also been proven to be efficient in the C-C bond activation reaction [14,15].In 2008, Li's group reported FeCl 2 -catalyzed selective C-C bond formation via the oxidative activation of a benzylic C-H bond.Additionally, the group found that C-C bond formation is a reversible process [16].Then, we reported approaches for C-C bond cleavage to form new C-C bond [17] and C-N bond [18] reactions based on the iron-catalyzed β-C-C bond activation of 1,3-diketones (Scheme 1a).In these works, indole, alkene, alkyne, amine, and amide were used as nucleophiles.
Ketones are weak nucleophiles.To broaden the application of C-C bond activation reactions, ketones, which can be easily converted into enols, were used as nucleophiles.Usually, ketones are transformed into metal enolates [19,20] or enamines [21] and then are reacted with carbon electrophiles to obtain α-alkylated ketones.We propose that the key step in this transformation is the shift in the equilibrium towards enol formation.Thus, adding additives or catalysts to active ketones may promote the desired conversion.Obviously, it is known that the trace residues of transition metals are often difficult to remove from the final products used in pharmaceutical applications [22].Consequently, it is necessary to develop metal-free selective C-C bond activation reactions.Base or Brønsted acid-catalyzed C-C bond cleavage reactions mainly occur in intramolecular rearrangement reactions [23,24] and tension ring-opening reactions [25].Therefore, we need to design a proper catalyst system that can activate both C-C bonds and ketone substrates.Based on our previous work and reports from the literature [17,18,26], the β-C-C bond cleavage of ketones can be catalyzed by Lewis acids, and we envision that Brøsted acid may participate in this reaction, which can also promote the conversion from ketone to enol.Hence, we report a novel Brønsted acid-catalyzed C-C bond cleavage and the direct α-alkylation of ketone reactions (Scheme 1b).To the best of our knowledge, the chemistry of the Bronsted acid-catalyzed β-C-C bond activation of carbonyl groups has not been reported.At the same time, this report has a broader substrate scope than previous reports for the α-alkylation of ketones [26].Ketones are weak nucleophiles.To broaden the application of C-C bond activation reactions, ketones, which can be easily converted into enols, were used as nucleophiles.Usually, ketones are transformed into metal enolates [19,20] or enamines [21] and then are reacted with carbon electrophiles to obtain α-alkylated ketones.We propose that the key step in this transformation is the shift in the equilibrium towards enol formation.Thus, adding additives or catalysts to active ketones may promote the desired conversion.Obviously, it is known that the trace residues of transition metals are often difficult to remove from the final products used in pharmaceutical applications [22].Consequently, it is necessary to develop metal-free selective C-C bond activation reactions.Base or Brønsted acid-catalyzed C-C bond cleavage reactions mainly occur in intramolecular rearrangement reactions [23,24] and tension ring-opening reactions [25].Therefore, we need to design a proper catalyst system that can activate both C-C bonds and ketone substrates.Based on our previous work and reports from the literature [17,18,26], the β-C-C bond cleavage of ketones can be catalyzed by Lewis acids, and we envision that Brøsted acid may participate in this reaction, which can also promote the conversion from ketone to enol.Hence, we report a novel Brønsted acid-catalyzed C-C bond cleavage and the direct α-alkylation of ketone reactions (Scheme 1b).To the best of our knowledge, the chemistry of the Bronsted acid-catalyzed β-C-C bond activation of carbonyl groups has not been reported.At the same time, this report has a broader substrate scope than previous reports for the α-alkylation of ketones [26].

Optimization Studies
To test our hypothesis, we initiated an investigation on the model reaction of 2-benzhydryl-1,3-diphenylpropane-1,3-dione 1a and propiophenone 2a to search for a potential acid catalyst and suitable reaction conditions.The desired product was obtained in a 15%

Optimization Studies
To test our hypothesis, we initiated an investigation on the model reaction of 2benzhydryl-1,3-diphenylpropane-1,3-dione 1a and propiophenone 2a to search for a potential acid catalyst and suitable reaction conditions.The desired product was obtained in a 15% yield in the presence of 20 mol% FeCl 3 (Table 1, entry 1).The reaction almost stopped when 20 mol% base or amine was added in order to form the enolates or enamines of ketones (Table 1, entries 2-5), probably due to the low activation of the C-C bond.When 20 mol% trifluoromethanesulfonic acid (TfOH) was used as a catalyst with 20 mol% FeCl 3 , the desired product was detected in a 18% yield.Fortunately, when only TfOH was used as a catalyst, 1a reacted with the 1.0 equivalent of 2a in DCE at 100 • C for 1 h, and the desired product was obtained in a 52% yield (Table 1, entry 7).MeSO 3 H was less effective for this transformation (Table 1, entry 8), and the desired product was not generated when another weaker Brønsted acid was used, such as TFA, AcOH, and benzoic acid (Table 1, entries [9][10][11].A reasonable yield of 3a was detected when BF 4 H was used as a catalyst because of the coordination between the catalyst and 1a activating the C-C bond (Table 1, entry 12).To our delight, the α-alkylation reaction could be achieved in a higher yield by increasing the amount of 2a and the catalyst TfOH (Table 1, entries 14 and 15).An excellent result was obtained when the 2 equivalent of 2a was used with 30 mol% TfOH in DCE at 100 • C for 3 h (Table 1, entry 16).Moreover, other solvents were inferior to DCE with regard to the yield of the desired product, such as THF (<5%), MeCN (60%) and chlorobenzene (49%) (Table 1, entries [17][18][19][20].Notably, product 3a was not observed in the absence of TfOH acid (Table 1, entry 21).increasing the amount of 2a and the catalyst TfOH (Table 1, entries 14 and 15).An excellent result was obtained when the 2 equivalent of 2a was used with 30 mol% TfOH in DCE at 100 o C for 3 h (Table 1, entry 16).Moreover, other solvents were inferior to DCE with regard to the yield of the desired product, such as THF (<5%), MeCN (60%) and chlorobenzene (49%) (Table 1, entries [17][18][19][20].Notably, product 3a was not observed in the absence of TfOH acid (Table 1, entry 21).

Substrate Scope Studies
With the optimized reaction conditions established, the scope of the present transformation was examined using 2a as a model substrate to react with various ketones.As shown in Table 2, both aromatic ketones and aliphatic ketones could be effectively transformed into the corresponding product 3.The aromatic ketones reacted with 1a efficiently and produced the corresponding compounds 3a and 3b in moderate to good yields (Table 2, entries 1-3).The monoalkylation product was highly selectively generated in an excellent yield when 2c was used in the reaction (

Substrate Scope Studies
With the optimized reaction conditions established, the scope of the present transformation was examined using 2a as a model substrate to react with various ketones.As shown in Table 2, both aromatic ketones and aliphatic ketones could be effectively transformed into the corresponding product 3.The aromatic ketones reacted with 1a efficiently and produced the corresponding compounds 3a and 3b in moderate to good yields (Table 2, entries 1-3).The monoalkylation product was highly selectively generated in an excellent yield when 2c was used in the reaction (Table 2, entry 4).α-Substituted ketone 2d provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.
Subsequently, we examined the scope of ketones with electron-withdrawing groups under the optimized reaction conditions.Various 1,3-dicarbonyl compounds were transformed into the corresponding products 3 with good to excellent yields.To our delight, almost-quantitative yields of the desired products were obtained when 1,3-keto esters were used in the reaction (Table 2, entries 8 and 9).The cyclic 1,3-dicarbonyl substrate could also react with 1a, giving the corresponding products in moderate yields because of the influence of steric effects (Table 2, entries 10 and 11).Ketones with strong electron-withdrawing groups, such as cyano and sulfonyl, could also afford the corresponding products with excellent yields (Table 2, entries 12 and 13).Furthermore, with both the electron-donating group and electron-withdrawing group on the ring of 2-benzhydryl-1,3-diphenylpropane-1,3-dione 1a, the corresponding products could be obtained in excellent yields (Table 2, entries 14 and 15).provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.provided the completely regioselective product 3d in a good yield.Aliphatic ketones could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.could also be transformed smoothly into the corresponding products in moderate yields by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.by increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.increasing the amount of catalyst with high regioselectivity.Interestingly, the ketone 2g could also give the α-alkylation product, while the yield of the desired product was not satisfactory.Subsequently, we examined the scope of ketones with electron-withdrawing groups under the optimized reaction conditions.Various 1,3-dicarbonyl compounds were transformed into the corresponding products 3 with good to excellent yields.To our delight, almost-quantitative yields of the desired products were obtained when 1,3-keto esters were used in the reaction (Table 2, entries 8 and 9).The cyclic 1,3-dicarbonyl substrate could also react with 1a, giving the corresponding products in moderate yields because of the influence of steric effects (Table 2, entries 10 and 11).Ketones with strong electronwithdrawing groups, such as cyano and sulfonyl, could also afford the corresponding products with excellent yields (Table 2, entries 12 and 13).Furthermore, with both the electron-donating group and electron-withdrawing group on the ring of 2-benzhydryl-1,3-diphenylpropane-1,3-dione 1a, the corresponding products could be obtained in excellent yields (Table 2, entries 14 and 15).

Proposed Mechanism for Brønsted Acid-Catalyzed C-C Bond Activation
To investigate the possible pathways of the present C-C bond cleavage, enol esters, instead of ketones, were reacted with 1a.Enol esters 4 and 5, which have stable enol structures, were chosen as substrates [27,28].α-alkylation product 3a was obtained in 65% yield and the conversion of 1a was 66% in the reaction of 1a with the 2 equivalent of 4. 3b was observed in 96% yields in the reaction of 1a with 5 (Scheme 2).These results indicate that the reaction most likely proceeds through an enol isomer mechanism.Subsequently, we examined the scope of ketones with electron-withdrawing groups under the optimized reaction conditions.Various 1,3-dicarbonyl compounds were transformed into the corresponding products 3 with good to excellent yields.To our delight, almost-quantitative yields of the desired products were obtained when 1,3-keto esters were used in the reaction (Table 2, entries 8 and 9).The cyclic 1,3-dicarbonyl substrate could also react with 1a, giving the corresponding products in moderate yields because of the influence of steric effects (Table 2, entries 10 and 11).Ketones with strong electronwithdrawing groups, such as cyano and sulfonyl, could also afford the corresponding products with excellent yields (Table 2, entries 12 and 13).Furthermore, with both the electron-donating group and electron-withdrawing group on the ring of 2-benzhydryl-1,3-diphenylpropane-1,3-dione 1a, the corresponding products could be obtained in excellent yields (Table 2, entries 14 and 15).

Proposed Mechanism for Brønsted Acid-Catalyzed C-C Bond Activation
To investigate the possible pathways of the present C-C bond cleavage, enol esters, instead of ketones, were reacted with 1a.Enol esters 4 and 5, which have stable enol structures, were chosen as substrates [27,28].α-alkylation product 3a was obtained in 65% yield and the conversion of 1a was 66% in the reaction of 1a with the 2 equivalent of 4. 3b was observed in 96% yields in the reaction of 1a with 5 (Scheme 2).These results indicate that the reaction most likely proceeds through an enol isomer mechanism.

Proposed Mechanism for Brønsted Acid-Catalyzed C-C Bond Activation
To investigate the possible pathways of the present C-C bond cleavage, enol esters, instead of ketones, were reacted with 1a.Enol esters 4 and 5, which have stable enol structures, were chosen as substrates [27,28].α-alkylation product 3a was obtained in 65% yield and the conversion of 1a was 66% in the reaction of 1a with the 2 equivalent of 4. 3b was observed in 96% yields in the reaction of 1a with 5 (Scheme 2).These results indicate that the reaction most likely proceeds through an enol isomer mechanism.
a Conditions: 1 (0.2 mmol), 2 (0.4 mmol), TfOH (0.06 mmol), DCE (3 mL), 100 °C, 3 h.b Yields refer to the isolated yields.c TfOH (0.1 mmol).d 1 h.Subsequently, we examined the scope of ketones with electron-withdrawing groups under the optimized reaction conditions.Various 1,3-dicarbonyl compounds were transformed into the corresponding products 3 with good to excellent yields.To our delight, almost-quantitative yields of the desired products were obtained when 1,3-keto esters were used in the reaction (Table 2, entries 8 and 9).The cyclic 1,3-dicarbonyl substrate could also react with 1a, giving the corresponding products in moderate yields because of the influence of steric effects (Table 2, entries 10 and 11).Ketones with strong electronwithdrawing groups, such as cyano and sulfonyl, could also afford the corresponding products with excellent yields (Table 2, entries 12 and 13).Furthermore, with both the electron-donating group and electron-withdrawing group on the ring of 2-benzhydryl-1,3-diphenylpropane-1,3-dione 1a, the corresponding products could be obtained in excellent yields (Table 2, entries 14 and 15).

Proposed Mechanism for Brønsted Acid-Catalyzed C-C Bond Activation
To investigate the possible pathways of the present C-C bond cleavage, enol esters, instead of ketones, were reacted with 1a.Enol esters 4 and 5, which have stable enol structures, were chosen as substrates [27,28].α-alkylation product 3a was obtained in 65% yield and the conversion of 1a was 66% in the reaction of 1a with the 2 equivalent of 4. 3b was observed in 96% yields in the reaction of 1a with 5 (Scheme 2).These results indicate that the reaction most likely proceeds through an enol isomer mechanism.On the basis of these experimental results, a possible mechanism for the acid-catalyzed C-C bond cleavage and α-alkylation of ketones is shown in Scheme 3. Firstly, 1,3-dicarbonyl compounds 1a are protonated under strong acid conditions, and enol tautomerization promotes C-C bond cleavage, resulting in the formation of diphenylmethane cations 7.At the same time, the catalyst TfOH promotes the conversion from ketone to enol 10 through protonation of carbonyl group and the deprotonation of α-H in ketone.Then, 10 can capture 7 to promote the α-alkylation of ketone 11, subsequently dehydrogenating protons to obtain the target product 3.Of course, we do not rule out the possibility of electron pairs being present in the dicarbonyl compounds, and this is currently being studied.electron pairs being present in the dicarbonyl compounds, and this is currently being studied.

General Information
Reagents were purchased from commercial sources and used directly without further purification unless otherwise mentioned. 1H NMR (400 MHz) and 13 C NMR (101 MHz) spectra were recorded on a Bruker 400 spectrometer (Bruker Corporation, Berlin, Germany).Chemical shifts are reported in parts per million (ppm) relative to internal standard tetramethylsilane (0.00 ppm) residues of CHCl3 (7.26 ppm).The spectra were collected in CDCl3.Data are indicated as follows: s = singlet; d = doublet; dd = doublet of Scheme 3. Proposed reaction mechanism.

General Information
Reagents were purchased from commercial sources and used directly without further purification unless otherwise mentioned. 1H NMR (400 MHz) and 13 C NMR (101 MHz) spectra were recorded on a Bruker 400 spectrometer (Bruker Corporation, Berlin, Germany).Chemical shifts are reported in parts per million (ppm) relative to the internal standard tetramethylsilane (0.00 ppm) or residues of CHCl 3 (7.26 ppm).The spectra were collected in CDCl 3 .Data are indicated as follows: s = singlet; d = doublet; dd = doublet of doublet; t = triplet; m = multiplet; and q = quartet.Mass spectra (HRMS and ESI-MS) were obtained on an APEX II (Bruker Corporation, Berlin, Germany).IR spectra were collected on a Nicolet 5MX-S infrared spectrometer (Thermo Fisher Scientific, Waltham, MA, USA).

General Experimental Procedure of Reaction of 1a and Enol Ester
To a mixture of 2-benzhydryl-1,3-diphenyl-propane-1,3-dione 1a (0.2 mmol), (Z)-1-phenylprop-1-en-1-yl acetate 4 (0.4 mmol) in DEC (2 mL), TfOH (0.06 mmol, freshly prepared 0.1 M in DCE) was added under N 2 at rt.The resulting mixture was stirred at 100 • C for 3 h in a sealed pressure tube.Then, the reaction was cooled to rt.The resulting reaction solution was evaporated in a vacuum to give the crude products.The desired product was purified via flash column chromatography on silica gel using ethyl acetate/petroleum ether (1:50) as an eluent.

Conclusions
In summary, we developed a novel and efficient approach for the Brønsted acidcatalyzed β-C-C bond cleavage of carbonyl groups under mild reaction conditions.Both aromatic and aliphatic ketones could participate in the reaction with high yields and excellent regioselectivity.The reversible C-C bond cleavage and equilibrium from ketone to enol are driving forces that induce the desired products.The scope, mechanism, and synthetic application are under investigation.

Scheme 2 . 7 . 1
Scheme 2. Acid-catalyzed α-alkylation of ketones from enol esters via C-C bond activation.a : 7 h On the basis of these experimental results, a possible mechanism for the acid-catalyzed C-C bond cleavage and α-alkylation of ketones is shown in Scheme 3. Firstly, 1,3dicarbonyl compounds 1a are protonated under strong acid conditions, and enol tautomerization promotes C-C bond cleavage, resulting in the formation of diphenylmethane cations 7.At the same time, the catalyst TfOH promotes the conversion from ketone to enol 10 through protonation of carbonyl group and the deprotonation of α-H in ketone.Then, 10 can capture 7 to promote the α-alkylation of ketone 11, subsequently dehydrogenating protons to obtain the target product 3.Of course, we do not rule out the possibility of

Scheme 2 . 7 .
Scheme 2. Acid-catalyzed α-alkylation of ketones from enol esters via C-C bond activation.a : 7 h On the basis of these experimental results, a possible mechanism for the acid-catalyzed C-C bond cleavage and α-alkylation of ketones is shown in Scheme 3. Firstly, 1,3dicarbonyl compounds 1a are protonated under strong acid conditions, and enol tautomerization promotes C-C bond cleavage, resulting in the formation of diphenylmethane cations 7.At the same time, the catalyst TfOH promotes the conversion from ketone to enol 10 through protonation of carbonyl group and the deprotonation of α-H in ketone.Then, 10 can capture 7 to promote the α-alkylation of ketone 11, subsequently dehydrogenating protons to obtain the target product 3.Of course, we do not rule out the possibility of

Scheme 2 . 7 .
Scheme 2. Acid-catalyzed α-alkylation of ketones from enol esters via C-C bond activation.a : 7 h On the basis of these experimental results, a possible mechanism for the acid-catalyzed C-C bond cleavage and α-alkylation of ketones is shown in Scheme 3. Firstly, 1,3dicarbonyl compounds 1a are protonated under strong acid conditions, and enol tautomerization promotes C-C bond cleavage, resulting in the formation of diphenylmethane cations 7.At the same time, the catalyst TfOH promotes the conversion from ketone to enol 10 through protonation of carbonyl group and the deprotonation of α-H in ketone.Then, 10 can capture 7 to promote the α-alkylation of ketone 11, subsequently dehydrogenating protons to obtain the target product 3.Of course, we do not rule out the possibility of Scheme 2. Acid-catalyzed α-alkylation of ketones from enol esters via C-C bond activation.a : 7 h.

Table 1 .
Optimization of the reaction conditions a .

Table 1 .
Optimization of the reaction conditions a . .